Cancer and Chemotherapy
One of the major uses of medical cannabis in the US is cancer related pain and chemotherapy related side-effects. Those on medical cannabis show better tolerance to chemotherapy. Studies have shown that cannabis significantly reduces chemotherapy induced nausea and vomiting (CINV).

One of the major uses of medical cannabis in the US is cancer related pain and chemotherapy related side-effects. Those on medical cannabis show better tolerance to chemotherapy. Studies have shown that cannabis significantly reduces chemotherapy induced nausea and vomiting (CINV).
CB1 and CB2 receptors have been shown to be involved in many types of cancer (breast cancer, prostate cancer, hepatocellular carcinoma, non-small cell carcinoma, pancreatic cancer, melanoma and chronic lymphocytic leukemia) and hence there is definite interest in cannabinoids as novel therapies for cancer.
Animal studies have shown that cannabinoids might have varied role in cancers. They can induce cell cycle arrest, promote apoptosis (cell-death) and inhibit proliferation. So these can help arrest the growth of the tumor. It also affects migration (metastasis) and angiogenesis (blood-vessel formation) in the tumor.
Cannabinoids were able to effectively modulate tumor growth in different in vitro and in vivo cancer models, however, these anticancer effects appears to be dependent on cancer type and drug dose.
References:
Cannabinoids in cancer treatment: Therapeutic potential and legislation. Barbara Dariš et al. Bosn J Basic Med Sci. 2019 Feb; 19(1): 14–23. doi: 10.17305/bjbms.2018.3532
Use of Cannabis and Cannabinoids in Patients With Cancer. Lindsey Sawtelle, Lisa M Holle. Ann Pharmacother. 2021 Jul;55(7):870-890. doi: 10.1177/1060028020965224. Epub 2020 Oct 17.
Cannabidiol (CBD) as a Promising Anti-Cancer Drug. Emily S. Seltzer et al. Cancers (Basel). 2020 Nov; 12(11): 3203. Published online 2020 Oct 30. doi: 10.3390/cancers12113203