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Skin disease ( dry eczema, inflammation etc)

Skin biology is modulated distinctly by the ECS. CBD, in particular, has gathered much interest lately because pre-clinical studies have shown promising results in conditions like psoriasis, eczema, inflammatory condition and pruritis.

Skin disease ( dry eczema, inflammation etc)

Skin biology is modulated distinctly by the ECS. CBD, in particular, has gathered much interest lately because pre-clinical studies have shown promising results in conditions like psoriasis, eczema, inflammatory condition and pruritis. Cannabinoids are anti-pruritic (anti-itching) and reduce skin turnover (thereby preventing accumulation of dead cells in the skin)

In a recent study, CBD was shown to exhibit anti-inflammatory properties in an experimental, allergic contact dermatitis model.

Severity of dermatitis is sometimes influenced by the bacterial composition of the skin (biofilm formation of strep. Aureus). The preliminary data indicating the antimicrobial and antibiofilm activity of hemp come from the essential oil (steam distillate) fraction of hemp which is composed mainly of terpenoids such as myrcene, α-pinene, β-caryophyllene and other terpenes.

Topical application (without any THC) has been shown to be effective in various inflammatory skin disorders.

Wound healing has been shown to be affected by the synergistic action of terpenoids, flavonoids and cannabinoids. It down regulates inflammation and promotes wound healing as per per-clinical studies

Acne:

The major factors involved in acne onset are sebum(oil) overproduction, unwanted sebocyte proliferation, and inflammation. CBD not just simply reduces sebum (oil) production, but it also normalizes lipogenesis (lipid production) when it is in a state of imbalance. So, CBD systemically helps in regulating acne.
Another study concluded that Hemp seed extract or hemp EO could also have potential for treating acne vulgaris because of its anti-lipogenic, anti-proliferative, anti-inflammatory, and anti-microbial, properties, which may target similar or independent mechanisms than that of CBD.

Cannabinoids have not be researched completely in pigmentation disorders and hair fall (alopecia). Hence, their role in these issues are very limited.

Reference:

Petrosino S, et al. Anti-inflammatory properties of cannabidiol, a nonpsychotropic cannabinoid, in experimental allergic contact dermatitis. J Pharmacology Experimental Therapeutics. 2018;365(3):652–663.

Mediavilla V, Steinemann S. Essential oil of Cannabis sativa L. strains. J Int Hemp Assoc. 1997;4:80–82.
Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders. Sudhir M Baswan et al. Clin Cosmet Investig Dermatol. 2020; 13: 927–942. Published online 2020 Dec 8. doi: 10.2147/CCID.S286411

A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars. B Palmieri et al. Clin Ter. Mar-Apr 2019;170(2):e93-e99. doi: 10.7417/CT.2019.2116.

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